Science

Guidelines for diagnosis and therapy of ANCA-associated vasculitides

In December 2017, the German Society for Rheumatology (DGRh) published their first guideline for the diagnosis and treatment of ANCA-associated forms of vasculitis (AAV) [1]. The AAV encompass granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome), which all occur with autoantibodies against cytoplasmic antigens […]

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Uromodulin – a protein with many clinical implications

Uromodulin, which was first described as Tamm-Horsfall protein in 1950, is an important biomarker in nephrology. The protein is exclusively expressed in the kidney and is mostly secreted into the renal tubules. A small amount also ends up in the blood circulation. Both uromodulin concentration in urine as well as in serum are used as

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Advantages of the modern allergy diagnostics

In the current issue of the medical journal Trillium Diagnostik (14(3): 172-173), Prof Dr Rudolf Gruber and Dr Gabriele Egert, experts for laboratory diagnostics, clearly explain the advantages of defined recombinant allergen components which are applied in modern molecular allergy diagnostics. While allergens which are extracted and purified from natural allergen sources always constitute a

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EUVAS study confirms efficiency of automated multiparametric immunofluorescene for detection of vasculitis-associated ANCA

Scientist of the European Vasculitis Study (EUVAS) group published the results of a recent study (Csernok et al., Autoimmunity Reviews 2016) testing the performance of two fully automated platforms for multiparametric ANCA IIFT diagnostics which combine cell substrates and monospecific antigen substrates: the EUROPLUS Granulocyte Mosaic (EUROPattern, Euroimmun AG) and CytoBead ANCA (Aklides, Medipan/Generic Assays

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