A current multicentre study shows that anti-nephrin autoantibodies can be a reliable biomarker for idiopathic nephrotic syndrome, which occurs in diseases such as minimal change disease (MCD). These antibodies were much more frequent in patients with the respective diseases than in those with other kidney diseases or in healthy persons. The antibody level also correlates […]
A collaborative study with Euroimmun, published recently in the journal Brain, has identified septin multimer as a novel target of autoimmunity in patients with severe motor neuropathy. The autoantibodies may represent a new biomarker for a rare but clinically significant disease subgroup. What are septins? Septins are a family of ubiquitously expressed cytoskeletal proteins
A new study from Euroimmun, published in PLoS Neglected Tropical Diseases, demonstrates how customised testing for different dengue serological markers can improve diagnostic accuracy across different stages of infection. Diagnostic challenges Accurate diagnosis of dengue virus (DENV) infection is challenging due to its non-specific early symptoms and potential for rapid clinical deterioration. While RT-PCR is
A study on Oropouche virus (OROV) has shed light on recent and historical outbreaks of this neglected virus in Latin America and the Caribbean. The study was performed in collaboration with Euroimmun and Euroimmun Brazil and was published in Nature Medicine. Background to Oropouche virus OROV is an arbovirus that causes the febrile illness Oropouche
Identifying autoimmune encephalitis (AIE) in patients with psychiatric symptoms is challenging, especially since many associated autoantibodies are rare and not routinely tested. A recent case study of steroid-responsive psychosis linked to anti-septin-7 antibodies — characterised in collaboration with Euroimmun and published in Translational Psychiatry — highlights the need to consider autoimmune causes in primary mental
