Uromodulin – a protein with many clinical implications

Uromodulin, which was first described as Tamm-Horsfall protein in 1950, is an important biomarker in nephrology. The protein is exclusively expressed in the kidney and is mostly secreted into the renal tubules. A small amount also ends up in the blood circulation. Both uromodulin concentration in urine as well as in serum are used as


Autoantibody diagnostics in autoimmune nephropathies

Autoimmune-mediated damage to the kidneys can be triggered by autoantibodies directed against renal proteins, as in the case of primary membranous nephropathy (MN) or Goodpasture syndrome, or may occur secondary as part of the wide-reaching effects of systemic autoimmune diseases such as vasculitis or systemic lupus erythematosus (SLE). The detection of specific autoantibodies in patient


Early identification of kidney impairment using the Uromodulin ELISA

Uromodulin is a kidney-specific glycoprotein, which is mainly secreted in the urine but also, in small amounts, into the bloodstream. Since it was discovered several years ago that mutations and certain polymorphisms in the uromodulin-coding gene (UMOD)  are associated with various kidney disorders and kidney vitality, the protein has been increasingly researched. Today, uromodulin is


Uromodulin: an important biomarker in nephrology

Uromodulin is a kidney-specific glycoprotein, which is exclusively expressed by the epithelial cells of the ascending limb of loop of Henle (TAL cells) and secreted into the urine. There, it is the quantitatively most significant protein. Additionally, secretion of small quantities of uromodulin into the interstitium was described. In this way the proteins gets into

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