Science

Guidelines for diagnosis and therapy of ANCA-associated vasculitides

In December 2017, the German Society for Rheumatology (DGRh) published their first guideline for the diagnosis and treatment of ANCA-associated forms of vasculitis (AAV) [1]. The AAV encompass granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome), which all occur with autoantibodies against cytoplasmic antigens

Science

Uromodulin – a protein with many clinical implications

Uromodulin, which was first described as Tamm-Horsfall protein in 1950, is an important biomarker in nephrology. The protein is exclusively expressed in the kidney and is mostly secreted into the renal tubules. A small amount also ends up in the blood circulation. Both uromodulin concentration in urine as well as in serum are used as

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