Nephrology Archive - Euroimmun Blog https://www.euroimmunblog.com/tag/nephrology-de/ Forschung, Wissenschaft und Diagnostik Fri, 30 Aug 2019 07:57:22 +0000 en-US hourly 1 https://www.euroimmunblog.com/wp-content/uploads/2025/08/cropped-favicon_256x256-32x32.png Nephrology Archive - Euroimmun Blog https://www.euroimmunblog.com/tag/nephrology-de/ 32 32 New ELISA for determination of the renal inflammation marker sCD163 https://www.euroimmunblog.com/new-elisa-for-determination-of-the-renal-inflammation-marker-scd163/ https://www.euroimmunblog.com/new-elisa-for-determination-of-the-renal-inflammation-marker-scd163/#respond Fri, 30 Aug 2019 07:57:22 +0000 https://www.euroimmunblog.com/?p=4989 The new EUROIMMUN ELISA for detection of soluble CD163 (sCD163) in urine is now available. This is the first CE-certified test for this parameter on the market. Mark Little, Professor for nephrology at the Trinity College in Dublin (Ireland) showed in a study that increased concentrations of sCD163 in urine indicate an inflammation of the […]

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Uromodulin – a protein with many clinical implications https://www.euroimmunblog.com/uromodulin-new-clinical-associations-html/ https://www.euroimmunblog.com/uromodulin-new-clinical-associations-html/#respond Tue, 17 Oct 2017 08:48:56 +0000 http://www.euroimmunblog.com/?p=3996 Uromodulin, which was first described as Tamm-Horsfall protein in 1950, is an important biomarker in nephrology. The protein is exclusively expressed in the kidney and is mostly secreted into the renal tubules. A small amount also ends up in the blood circulation. Both uromodulin concentration in urine as well as in serum are used as […]

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Autoantibody diagnostics in autoimmune nephropathies https://www.euroimmunblog.com/autoantibody-diagnostics-in-autoimmune-nephropathies/ https://www.euroimmunblog.com/autoantibody-diagnostics-in-autoimmune-nephropathies/#respond Tue, 22 Sep 2015 10:10:53 +0000 http://www.euroimmunblog.com/?p=2265 Autoimmune-mediated damage to the kidneys can be triggered by autoantibodies directed against renal proteins, as in the case of primary membranous nephropathy (MN) or Goodpasture syndrome, or may occur secondary as part of the wide-reaching effects of systemic autoimmune diseases such as vasculitis or systemic lupus erythematosus (SLE). The detection of specific autoantibodies in patient […]

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Early identification of kidney impairment using the Uromodulin ELISA https://www.euroimmunblog.com/early-identification-of-kidney-impairment-using-the-uromodulin-elisa/ Tue, 28 Apr 2015 09:21:12 +0000 http://www.euroimmunblog.com/?p=1773 Uromodulin is a kidney-specific glycoprotein, which is mainly secreted in the urine but also, in small amounts, into the bloodstream. Since it was discovered several years ago that mutations and certain polymorphisms in the uromodulin-coding gene (UMOD)  are associated with various kidney disorders and kidney vitality, the protein has been increasingly researched. Today, uromodulin is […]

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Uromodulin: an important biomarker in nephrology https://www.euroimmunblog.com/uromodulin-an-important-biomarker-in-nephrology/ https://www.euroimmunblog.com/uromodulin-an-important-biomarker-in-nephrology/#respond Mon, 27 Apr 2015 13:07:02 +0000 http://www.euroimmunblog.de/?p=1681 Uromodulin is a kidney-specific glycoprotein, which is exclusively expressed by the epithelial cells of the ascending limb of loop of Henle (TAL cells) and secreted into the urine. There, it is the quantitatively most significant protein. Additionally, secretion of small quantities of uromodulin into the interstitium was described. In this way the proteins gets into […]

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