Science

EUVAS study confirms efficiency of automated multiparametric immunofluorescene for detection of vasculitis-associated ANCA

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Scientist of the European Vasculitis Study (EUVAS) group published the results of a recent study (Csernok et al., Autoimmunity Reviews 2016) testing the performance of two fully automated platforms for multiparametric ANCA IIFT diagnostics which combine cell substrates and monospecific antigen substrates: the EUROPLUS Granulocyte Mosaic (EUROPattern, Euroimmun AG) and CytoBead ANCA (Aklides, Medipan/Generic Assays […]

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23 at one swoop

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Using the EUROLINE ANA Profil 23 a patient sample can be tested for autoantibodies against 23 different nuclear antigens in one incubation. They are considered as the most important antigens which underlie the nuclear ANA patterns defined by an international consensus. For more than 50 years the abbreviation “ANA” has been used to describe anti-nuclear antibodies which

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Anti-CCP and Anti-CEP-1 ELISA for the diagnosis of rheumatoid arthritis

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which causes severe damage to the joints and leads to serious mobility impairment in the affected persons. RA cannot be cured, but can nowadays be treated, if diagnosed on time. In contrast to rheumatoid factors (RF), antibodies against the so-called citrullinated peptides (anti-citrullinated peptide antibodies, ACPA)

Science

Autoimmunity in rheumatoid arthritis

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Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Its development is stimulated by genetic and environmental risk factors. It is not very long ago that the relevant autoantigens in RA were identified. So-called citrullinated proteins (they contain the amino acid citrulline) are one of possibly several target antigens of

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